Neidle S, Taylor G, Sanderson M
Nucleic Acids Res. 1978 Nov;5(11):4417-22. doi: 10.1093/nar/5.11.4417.
The structure of a 1"2 complex of adenylyl-(3',5')-adenosine phosphate and proflavine hemisulfate has been determined using the methods of x-ray crystallography. Since the ApA does not form a mini double helix, it may serve as a model for the interaction of planar molecules with single stranded nucleic acids. The dinucleotide adopts an extended conformation with the adenines in adjacent molecules forming base pairs. A most unusual feature of the molecule is that it does not obey the "rigid nucleotide" concept although none of the torsion angles occur in energetically unfavourable regions. This is most probably due to the strong interactions between the proflavine and the oligonucleotide.
已使用X射线晶体学方法确定了腺苷酰基 -(3',5') - 磷酸腺苷与硫酸普罗黄素1:2复合物的结构。由于ApA不形成微型双螺旋,它可作为平面分子与单链核酸相互作用的模型。二核苷酸呈伸展构象,相邻分子中的腺嘌呤形成碱基对。该分子最不寻常的特征是它不遵循“刚性核苷酸”概念,尽管没有一个扭转角出现在能量不利区域。这很可能是由于普罗黄素与寡核苷酸之间的强相互作用。