Raju U, Kadner S, Levitz M, Kaganowicz A, Blaustein A
Steroids. 1981 Apr;37(4):399-407. doi: 10.1016/0039-128x(81)90042-8.
The metabolism of 3H-androsterone was studied in homogenates (fortified with uridine 5'-diphosphoglucuronic acid and adenosine 3'-phosphate 5'-phosphosulfate) of eighteen breast tumors, one muscle underlying the primary breast carcinoma and metastatic axillary lymph nodes from a patient with suspected primary breast cancer. The major metabolites identified were less polar than androsterone. On saponification these lipoidal derivatives afforded androsterone as the only product (3 to 48%). Unmetabolized androsterone and lesser quantities of epiandrosterone, 5 alpha-androstane- alpha, 17 beta-diol and 5 alpha-androstane-3,17-dione comprised the free steroid fraction. Androsterone glucosiduronate was isolated (0.17-4.1%) from weight breast tumor homogenates and from the node tissue incubation (17%). There was no apparent correlation between glucuronyltransferase activity and histopathology or estrogen receptor content.
在来自一名疑似原发性乳腺癌患者的18个乳腺肿瘤、一个原发性乳腺癌下方的肌肉以及转移性腋窝淋巴结的匀浆（添加了尿苷5'-二磷酸葡萄糖醛酸和腺苷3'-磷酸5'-磷酸硫酸酯）中研究了3H-雄甾酮的代谢。鉴定出的主要代谢物比雄甾酮的极性小。皂化后，这些脂类衍生物仅产生雄甾酮作为唯一产物（3%至48%）。未代谢的雄甾酮以及少量的表雄甾酮、5α-雄甾烷-α,17β-二醇和5α-雄甾烷-3,17-二酮构成了游离类固醇部分。从乳腺肿瘤匀浆和淋巴结组织孵育物中分离出了雄甾酮葡萄糖醛酸苷（分别为0.17% - 4.1%和17%）。葡萄糖醛酸转移酶活性与组织病理学或雌激素受体含量之间没有明显的相关性。
