Coradello H, Lubec G, Simbruner G
Wien Klin Wochenschr. 1981 Feb 6;93(3):93-6.
Two newborn infants with congenital toxoplasmosis despite serological testing during pregnancy were observed at our premature and neonatal intensive care unit within a short time of one another. In one case the counter-regulatory late first test, performed only in the 26th week, was positive with a high titre. The immediately recommended treatment was not carried out. Apart from the signs of congenital generalized infection, the newborn infant already manifested chorioretinitis and encephalitis. In the second case the initially serologically-negative pregnant women became infected only during the 35th to 36th week of gestation, around the time of the third serological examination. The child was born with slight signs of general infection, but without CNS involvement. Immediate postnatal treatment resulted in complete cure. This shows that such rare cases which can no longer be detected by serological testing can be treated postnatally with good results.
在我们的早产儿和新生儿重症监护病房，短时间内先后观察到两名患有先天性弓形虫病的新生儿，尽管其母亲在孕期进行了血清学检测。其中一例，仅在孕26周进行的反向调节晚期首次检测呈高滴度阳性。但并未立即进行推荐的治疗。除了先天性全身感染的体征外，该新生儿已出现脉络膜视网膜炎和脑炎。在第二例中，最初血清学检测为阴性的孕妇在妊娠35至36周左右，即第三次血清学检查时才被感染。孩子出生时有轻微的全身感染体征，但无中枢神经系统受累。出生后立即进行治疗，结果完全治愈。这表明，血清学检测无法再检测出的此类罕见病例，出生后进行治疗可取得良好效果。
