Thomassen P A
Acta Obstet Gynecol Scand. 1981;60(2):173-6.
Twenty-five different bile acids were determined by gas chromatography-mass spectrometry in 24 hour urine specimens before and during treatment with a commercial contraceptive drug. Neither excretion pattern nor individual amounts of bile acids showed any change during treatment of 4 healthy women. One woman with a history of recurrent cholestasis of pregnancy showed a slight increase in the levels of S-ALAT and total amount of urinary bile acids one day before she stopped taking the pill because of generalized itching. Another patient had a normal pattern of urinary bile acids after one year with a daily intake of 10 mg of estradiol valerate.
采用气相色谱 - 质谱联用技术测定了24名健康女性在服用一种商业避孕药之前和服药期间24小时尿液样本中的25种不同胆汁酸。在对4名健康女性的治疗过程中，胆汁酸的排泄模式和个体含量均未显示出任何变化。一名有复发性妊娠胆汁淤积病史的女性，在因全身瘙痒停药前一天，血清谷丙转氨酶（S - ALAT）水平和尿胆汁酸总量略有升高。另一名患者在每日摄入10毫克戊酸雌二醇一年后，尿胆汁酸模式正常。
