IgG and other proteins associated with human carcinomas and cancer-free tissue from the same organs.

Eluates of different were prepared at 56 degrees C using a continuous flow technique. More IgG and other serum proteins were found in liver from patients with non-malignant diseases than in liver tissue from healthy control individuals. Cancer-free liver tissue from patients with carcinomas was similar to that of patients with non-malignant diseases, but liver metastases contained twice the amount of IgG. No differences were found between non-perfused carcinomas of the kidney and cancer-free renal tissue, whereas more IgG was present in perfused carcinomas of the kidney than in cancer-free renal tissue. Most eluates of the malignant tissues and of the cancer-free renal tissue showed a reduced ratio of albumin IgG compared to that of serum or extracts, indicating a binding of IgG to antigens and/or receptors.