体内与人类肿瘤相关的免疫球蛋白：结肠癌洗脱液中的IgG浓度
Immunoglobulins associated with human tumours in vivo: IgG concentrations in eluates of colonic carcinomas.
作者信息
MacSween J M, Eastwood S L
出版信息
Br J Cancer. 1980 Oct;42(4):503-9. doi: 10.1038/bjc.1980.272.
Abstract
The concentrations of IgG in acidic and 3MKCl eluates of resected colonic carcinomas and adjacent normal tissue were determined by radioimmunoassay. The mean concentration of IgG was significantly higher in both acidic and KCl eluates of primary Dukes Stage C tumours than Dukes Stage A tumours. These results provide direct evidence for increased fixation of IgG in vivo by human colonic cancers which had metastasized. Our results also raise the possibility that IgG is more tightly bound to the Stage C tumours. It is likely that this tumour-associated Ig represents antibody to tumour antigens or antigen-antibody complexes, bound to Fc receptors in the tumour.
摘要
通过放射免疫分析法测定了切除的结肠癌及相邻正常组织的酸性洗脱液和3M氯化钾洗脱液中IgG的浓度。原发性Dukes C期肿瘤的酸性洗脱液和氯化钾洗脱液中IgG的平均浓度均显著高于Dukes A期肿瘤。这些结果为已发生转移的人类结肠癌在体内IgG固定增加提供了直接证据。我们的结果还提出了IgG与C期肿瘤结合更紧密的可能性。这种肿瘤相关Ig很可能代表与肿瘤抗原或抗原 - 抗体复合物结合的抗体，该复合物与肿瘤中的Fc受体结合。
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