Lippe B, Hensen L, Mendoza G, Finerman M, Welch M
Am J Dis Child. 1981 Jul;135(7):634-6. doi: 10.1001/archpedi.1981.02130310040014.
Two patients seen in a six-month period had a diffuse, multisystem disorder characterized by edema of the extremities and face, rash, bone pain and tenderness, symptoms of increased intracranial pressure, and hypercalcemia. Both had been receiving extraordinarily high doses of vitamin A for some time. Serum vitamin A concentrations were markedly elevated, and serum vitamin D concentrations were normal. The history of excessive vitamin administration was only elicited following the detection of hypercalcemia. This is a potential complication of the administration of unregulated food supplements, stressing the need for complete dietary histories in the evaluation of multisystem disorders, with or without hypercalcemia.
在六个月期间诊治的两名患者患有弥漫性多系统疾病，其特征为四肢和面部水肿、皮疹、骨痛和压痛、颅内压升高症状以及高钙血症。两人都曾在一段时间内接受超大剂量的维生素A。血清维生素A浓度显著升高，而血清维生素D浓度正常。过量维生素摄入史是在检测到高钙血症后才发现的。这是无监管食品补充剂使用的潜在并发症，强调在评估多系统疾病（无论有无高钙血症）时了解完整饮食史的必要性。
