Yokoyama S
Am J Hum Genet. 1981 May;33(3):407-17.
The concept of social selection for deleterious genes has been introduced by considering two alleles at one locus. A social selection model is constructed by assuming that the fitness of an individual is determined by his or her own as well as the parental phenotypes. It is shown that the equilibrium gene frequency depends on the loss of fitness of an individual due to the trait (gamma), due to affected parents (beta), and the probability that the heterozygote develops the trait (h). With mutational changes from the wild-type allele to the deleterious gene at a rate of alpha per generation, the equilibrium frequency of deleterious genes is approximately alpha/hs for 0 less than h less than or equal to 1 and square root alpha/s for h = 0, where s = gamma + beta(1 -- gamma)/2. Implications of the social selection model have been discussed for several diseases in man.
有害基因的社会选择概念是通过考虑一个基因座上的两个等位基因引入的。通过假设个体的适合度由其自身以及父母的表型决定，构建了一个社会选择模型。结果表明，平衡基因频率取决于个体因该性状导致的适合度损失（γ）、因患病父母导致的适合度损失（β）以及杂合子出现该性状的概率（h）。每代以α的速率从野生型等位基因发生突变为有害基因时，对于0＜h≤1，有害基因的平衡频率约为α/hs；对于h = 0，平衡频率约为√α/s，其中s = γ + β(1 - γ)/2。已针对人类的几种疾病讨论了社会选择模型的意义。
