Yokoyama S
Am J Hum Genet. 1983 May;35(3):362-75.
Using Huntington disease, mental retardation, and schizophrenia, it has been shown that two individuals with identical genotypes or phenotypes have different fitnesses because of affected nuclear family members. Such fitness interaction seems to occur because of cultural and social reactions due to the presence of affected individuals, and the interaction has been termed "social selection." Without assuming any specific genetic control for the social behavior, we can study the effect of social behavior on the incidence of a genetic disease.
以亨廷顿舞蹈症、智力迟钝和精神分裂症为例,研究表明,由于受影响的核心家庭成员的存在,具有相同基因型或表型的两个人具有不同的适合度。这种适合度相互作用似乎是由于受影响个体的存在所引发的文化和社会反应而产生的,这种相互作用被称为“社会选择”。在不假定对社会行为有任何特定遗传控制的情况下,我们可以研究社会行为对遗传病发病率的影响。