Doxanas M T, Green W R, Iliff C E
Am J Ophthalmol. 1981 Jun;91(6):726-36. doi: 10.1016/0002-9394(81)90005-2.
We studied the clinical and histopathologic features of 165 basal cell carcinomas of the eyelids and classified the tumors into four types (nodular, ulcerative, morphea, and multicentric) that differ in incidence, results of incomplete excision, aggressiveness, and recurrence. The value of frozen-section monitoring of the surgical margins was evident. In 39 cases excised with monitoring of the surgical margins by frozen sections, there were no recurrences. In 126 cases treated by excisional biopsy without frozen-section monitoring, 34 (26.9%) were incompletely excised and seven (5.5%) recurred. The surgical treatment of basal cell carcinoma should always include the use of frozen-section monitoring of the surgical margins. This is especially important in the morphea, multicentric, and ulcerative types, in which the invasive extent of the tumor is often not apparent clinically. These forms are also more aggressive.
我们研究了165例眼睑基底细胞癌的临床和组织病理学特征,并将这些肿瘤分为四种类型(结节型、溃疡型、硬斑病样型和多中心型),它们在发病率、不完全切除结果、侵袭性和复发方面存在差异。手术切缘冰冻切片监测的价值是显而易见的。在39例通过冰冻切片监测手术切缘而切除的病例中,无复发情况。在126例未进行冰冻切片监测而行切除活检的病例中,34例(26.9%)切除不完全,7例(5.5%)复发。基底细胞癌的手术治疗应始终包括使用手术切缘冰冻切片监测。这在硬斑病样型、多中心型和溃疡型中尤为重要,因为这些类型肿瘤的侵袭范围在临床上往往不明显。这些类型的肿瘤也更具侵袭性。