Alekseeva G G, Zaripova Z Kh, Iukhlova N A
Probl Endokrinol (Mosk). 1978 Nov-Dec;24(6):13-9.
The changes in the content of STH and FFA in the blood and of catecholamines in the urine under the effect of insulin hypoglycemia were studied in 28 insulin-sensitive and 40 insulin-resistant patients suffering from diabetes mellitus. Patients with diabetes mellitus who needed 100 or more insulin units per 24 hours for compensation of the affection were referred to the insulin-resistant ones. In these cases a less pronounced elevation of the blood STH level and of urinary catecholamines was noted in response to insulin hypoglycemia. This was accompanied by a considerable reduction of lipolysis in the insulin-resistant patients. It is suggested that in the insulin-resistant patients, due to reduction of the STH and catecholamine stimuli, FFA is incapable of providing the necessary energy balance at the cellular level in insulin insufficiency. This accounts for an increased requirement in exogenous insulin in the insulin-resistant patients with diabetes mellitus. Reduction of the FFA and catecholamine reserves in the insulin-resistant patients suffering from diabetes mellitus is postulated to be one of the main factors in the resistance pathogenesis.
对28例胰岛素敏感型和40例胰岛素抵抗型糖尿病患者在胰岛素低血糖作用下血液中生长激素（STH）和游离脂肪酸（FFA）含量以及尿液中儿茶酚胺含量的变化进行了研究。每24小时需要100单位或更多胰岛素来代偿病情的糖尿病患者被归为胰岛素抵抗型。在这些情况下，胰岛素低血糖反应时血液中STH水平和尿儿茶酚胺升高不太明显。这伴随着胰岛素抵抗患者脂肪分解的显著减少。提示在胰岛素抵抗患者中，由于STH和儿茶酚胺刺激减少，在胰岛素不足时FFA无法在细胞水平提供必要的能量平衡。这解释了胰岛素抵抗型糖尿病患者对外源胰岛素需求增加的原因。推测胰岛素抵抗型糖尿病患者FFA和儿茶酚胺储备减少是抵抗发病机制的主要因素之一。
