Alekseeva G G, Avenirova Z A, Zaripova Z Kh
Probl Endokrinol (Mosk). 1976 May-Jun;22(3):6-11.
The level of the radioimmunological growth hormone, free fatty acids and sugar was determined in the blood on fasting stomach and after the intravenous injection of insulin in 45 patients suffering from diabetes mellitus, insulin-resistant and sensitive, with consideration to body weight. Patients requiring for compensation of diabetes mellitus 100 units and more of insulin per day were referred to the group of resistant cases. A significantly greater growth hormone content on fasting stomach 60 and 120 min after the administration of insulin was found in the sensitive patients with diabetes mellitus with a normal weight, in comparison with the group of healthy individuals; the content was also higher on fasting stomach and in 60 minutes in comparison with the group of sensitive diabetics with excessive weight. A conclusion was drawn on the significance in the resistance formation of prolonged and stable decompensation. A reduction of compensatory possibilities of the hypothalamo-hypophysial system in response to the insulin deficiency in diabetic patients resistant to insulin is supposed. Adiposity characterized by reduction of the insulin sensitivity increased the requirements to the regulating system and led to reduction of the compensatory reaction at the stage of less severe sensitive diabetes. No participation of free fatty acids in the resistance formation was revealed.
对45例糖尿病患者（包括胰岛素抵抗型和敏感型），根据体重，测定了空腹及静脉注射胰岛素后血液中放射免疫生长激素、游离脂肪酸和血糖的水平。每天需要100单位及以上胰岛素来控制糖尿病的患者被归为抵抗组。与健康个体组相比，体重正常的敏感型糖尿病患者在空腹及注射胰岛素后60和120分钟时，生长激素含量显著更高；与体重超重的敏感型糖尿病患者组相比，其空腹及60分钟时的生长激素含量也更高。得出了长期稳定失代偿在抵抗形成中的重要性的结论。推测胰岛素抵抗型糖尿病患者中，下丘脑 - 垂体系统对胰岛素缺乏的代偿能力降低。以胰岛素敏感性降低为特征的肥胖增加了对调节系统的需求，并导致在较轻敏感型糖尿病阶段代偿反应降低。未发现游离脂肪酸参与抵抗形成。
