Spesivtseva V G, Men'shikov V V, Beliakov N V, Mamaeva G G, Stepanova N I
Probl Endokrinol (Mosk). 1978 Nov-Dec;24(6):19-22.
Kinin system was investigated in 82 patients suffering from diabetes mellitus of various severity. To make pathogenetically substantiated pharmacological correction of the kinin system activity prodectin--kinin antagonist--was used in these patients. A conclusion was drawn that the blood plasma kinin system was activated in the patients with moderately severe and severe diabetes. The activity of total kallikrein and kininogen became normal against the background of prodectin treatment. The blood plasma kinin system activity was normalized simultaneously with the improvement of the diabetic angiopathies course.
对82例不同严重程度的糖尿病患者的激肽系统进行了研究。为了从发病机制上对激肽系统活性进行合理的药理纠正，在这些患者中使用了激肽拮抗剂普罗迪辛。得出的结论是，中度严重和重度糖尿病患者的血浆激肽系统被激活。在普罗迪辛治疗的背景下，总激肽释放酶和激肽原的活性恢复正常。血浆激肽系统活性在糖尿病血管病变病程改善的同时恢复正常。
