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[四氧嘧啶糖尿病对小肠黏膜酶活性的影响]

[Effect of alloxan diabetes on the enzyme activity of the mucous membrane of the small intestine].

作者信息

Rakhimov K R, Zaripov B Z

出版信息

Probl Endokrinol (Mosk). 1978 Nov-Dec;24(6):85-9.

PMID:724680
Abstract

Experiments on male rats showed that following subcutaneous injection of alloxan in a dose of 15 mg per 100 g of body weight amylolytic, invertase, glycyl-l-tyrosine dipeptidehydrolase activity of the mucosa of the small intestine altered differently. As a result, there occurred a deviation of the enzymatic spectrum from the normal characterized by a sharp increase (with the development of diabetes) of the activity of the carbohydrate hydrolysing enzymes (amylase and invertase) with a simultaneous reduction of the activity of the enzymes participating in protein (dipeptidase) and fat (monglyceridlipase) hydrolysis.

摘要

对雄性大鼠的实验表明,皮下注射剂量为每100克体重15毫克的四氧嘧啶后,小肠黏膜的淀粉分解酶、转化酶、甘氨酰-L-酪氨酸二肽水解酶的活性发生了不同变化。结果,酶谱出现了与正常情况的偏差,其特征是碳水化合物水解酶(淀粉酶和转化酶)的活性急剧增加(随着糖尿病的发展),同时参与蛋白质(二肽酶)和脂肪(甘油单酯脂肪酶)水解的酶的活性降低。

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