[Sensitivity of isolated adipose tissue to insulin and questions concerning the pathogenesis of diabetes mellitus in patients with chronic liver diseases].

Immunoreactive insulin level proved to be elevated in the blood serum on fasting stomach and at various periods after glucose administration in patients with cirrhosis of the liver with normal glucose tolerance. Reduced insulin sensitivity of the isolated adipose tissue was observed in patients with cirrhosis of the liver. The blood serum cortisol level in these patients failed to differ from such in healthy persons; that calls in doubt participation of this contrinsular hormone in the genesis of reduced insulin sensitivity in chronic diseases of the liver. Elevation of peripheral insulin resistance can promote development or detection of carbohydrate metabolism disturbances in patients with chronic diseases of the liver.