Magnuson B
Am J Otolaryngol. 1981 Feb;2(1):1-12. doi: 10.1016/s0196-0709(81)80002-6.
It has generally been assumed that a high negative pressure in the middle ear space results from obstruction of the eustachian tube and the subsequent gas resorption through the middle ear mucosa. There is clinical evidence that quite a different mechanism is operating. The present experimental study verifies, with direct pressure recordings in cases of the retraction type of cholesteatoma and related conditions, that a high negative pressure can be generated by an active evacuation of air through the eustachian tube. The high negative pressure induced may explain the development of tympanic membrane retraction and pocketing, and the subsequent development of cholesteatoma.
一般认为，中耳腔的高负压是由咽鼓管阻塞以及随后通过中耳黏膜的气体吸收所致。有临床证据表明，起作用的是一种截然不同的机制。本实验研究通过对胆脂瘤退缩型及相关病症进行直接压力记录验证，高负压可由通过咽鼓管主动排出空气产生。所诱导的高负压可能解释鼓膜内陷和袋状形成以及随后胆脂瘤的发展。
