Yamamoto-Fukuda Tomomi, Takahashi Haruo, Koji Takehiko
Department of Otolaryngology-Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan.
J Biomed Biotechnol. 2011;2011:394241. doi: 10.1155/2011/394241. Epub 2011 Apr 6.
Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism underlying its pathogenesis is limited. To investigate its pathogenesis, different animal models have been used. This paper provides a brief overview of the current status of research in the field of pathogenesis of middle ear acquired cholesteatoma, four types of animal models previously reported on, up-to-date cholesteatoma research using these animal models, our current studies of the local hybrid ear model, and the future prospect of new animal models of middle ear cholesteatoma.
中耳后天性胆脂瘤是一种与中耳炎相关的病理状况，可能与颞骨吸收、耳漏和听力损失有关，偶尔还会出现各种其他并发症。胆脂瘤的特征是具有异常形态特征的上皮细胞增殖增强。不幸的是，我们对其发病机制的理解有限。为了研究其发病机制，人们使用了不同的动物模型。本文简要概述了中耳后天性胆脂瘤发病机制领域的研究现状、先前报道的四种动物模型、使用这些动物模型进行的最新胆脂瘤研究、我们目前对局部混合耳模型的研究以及中耳胆脂瘤新动物模型的未来前景。
