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克林霉素治疗弓形虫病。

Clindamycin therapy for toxoplasmosis.

作者信息

Ferguson J G

出版信息

Ann Ophthalmol. 1981 Jan;13(1):95-100.

PMID:7247166
Abstract

Clindamycin hydrochloride hydrate (Cleocin), a semisynthetic antibiotic shown experimentally to be effective in ocular toxoplasmosis in the rabbit, was used in the treatment of four patients with active retinochoroiditis secondary to toxoplasmosis. The drug was administered subjunctivally on alternate days for 30 days. Both subjective and objective evidence indicated beneficial results in these patients during the first 30 days. One of the four did not respond during the first 30 days but did respond during an extended period. One of those who responded initially had exacerbations when the drug was stopped and required treatment.

摘要

盐酸克林霉素水合物(氯洁霉素)是一种半合成抗生素,实验证明其对兔眼部弓形虫病有效,现用于治疗4例继发于弓形虫病的活动性视网膜脉络膜炎患者。药物隔日结膜下注射,共30天。主观和客观证据均表明,这些患者在最初30天内有良好疗效。4例中有1例在最初30天内无反应,但在延长疗程时有反应。最初有反应的患者中有1例在停药时病情加重,需要再次治疗。

相似文献

1
Clindamycin therapy for toxoplasmosis.克林霉素治疗弓形虫病。
Ann Ophthalmol. 1981 Jan;13(1):95-100.
2
[Clindamycin therapy of suspected toxoplasmosis retinochoroiditis].[克林霉素治疗疑似弓形虫性视网膜脉络膜炎]
Klin Monbl Augenheilkd. 1992 Feb;200(2):123-7. doi: 10.1055/s-2008-1045724.
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[Interest in treatment with subconjunctival clindamycin in toxoplasmic retinochoroiditis].[对结膜下注射克林霉素治疗弓形虫性视网膜脉络膜炎的研究兴趣]
Tunis Med. 2001 Mar;79(3):157-60.
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Intravitreal clindamycin for toxoplasmic retinochoroiditis.玻璃体内注射克林霉素治疗弓形虫性视网膜脉络膜炎。
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Short-term effects of the clindamycin-steroid regimen in the treatment of ocular toxoplasmosis.克林霉素-类固醇疗法治疗眼部弓形虫病的短期疗效
J Chemother. 1995 Nov;7 Suppl 4:199-201.
6
Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis.玻璃体内注射克林霉素和地塞米松治疗弓形虫性视网膜脉络膜炎。
Ophthalmic Surg Lasers. 2001 May-Jun;32(3):183-92.
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Atovaquone for the treatment of toxoplasma retinochoroiditis in immunocompetent patients.阿托伐醌用于治疗免疫功能正常患者的弓形虫性视网膜脉络膜炎。
Ophthalmology. 1999 Jan;106(1):148-53. doi: 10.1016/S0161-6420(99)90021-0.
8
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.眼部弓形虫病治疗的药物不良反应:一项回顾性病历审查。
Clin Ther. 2008 Nov;30(11):2069-74. doi: 10.1016/j.clinthera.2008.10.021.
9
[Value of clindamycin in the treatment of ocular toxoplasmosis].克林霉素在眼部弓形虫病治疗中的价值
J Fr Ophtalmol. 1997;20(6):418-22.
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Trimethoprim-sulfamethoxazole therapy for ocular toxoplasmosis.甲氧苄啶-磺胺甲恶唑治疗眼部弓形虫病。
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引用本文的文献

1
Safety of intravitreal clindamycin in albino rabbit eyes.玻璃体内注射克林霉素在白化兔眼中的安全性。
Doc Ophthalmol. 2017 Oct;135(2):133-146. doi: 10.1007/s10633-017-9599-5. Epub 2017 Jul 25.
2
Current treatment of toxoplasma retinochoroiditis: an evidence-based review.弓形虫性视网膜脉络膜炎的当前治疗:一项基于证据的综述。
J Ophthalmol. 2014;2014:273506. doi: 10.1155/2014/273506. Epub 2014 Aug 13.
3
Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial.
玻璃体内注射克林霉素联合地塞米松与经典口服疗法治疗弓形虫性视网膜脉络膜炎的前瞻性随机临床试验
Int Ophthalmol. 2013 Feb;33(1):39-46. doi: 10.1007/s10792-012-9634-1. Epub 2012 Sep 28.
4
Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats.克林霉素在猫实验性急性弓形虫病中的矛盾效应。
Antimicrob Agents Chemother. 1996 Jun;40(6):1352-9. doi: 10.1128/AAC.40.6.1352.
5
Ocular involvement in toxoplasmosis.眼部弓形虫病
Br J Ophthalmol. 1993 Jun;77(6):371-7. doi: 10.1136/bjo.77.6.371.
6
Therapy of ocular toxoplasmosis.
Int Ophthalmol. 1989 Dec;13(6):415-9. doi: 10.1007/BF02306491.