Clindamycin therapy for toxoplasmosis.

Clindamycin hydrochloride hydrate (Cleocin), a semisynthetic antibiotic shown experimentally to be effective in ocular toxoplasmosis in the rabbit, was used in the treatment of four patients with active retinochoroiditis secondary to toxoplasmosis. The drug was administered subjunctivally on alternate days for 30 days. Both subjective and objective evidence indicated beneficial results in these patients during the first 30 days. One of the four did not respond during the first 30 days but did respond during an extended period. One of those who responded initially had exacerbations when the drug was stopped and required treatment.