Day C L, Harrist T J, Gorstein F, Sober A J, Lew R A, Friedman R J, Pasternack B S, Kopf A W, Fitzpatrick T B, Mihm M C
Ann Surg. 1981 Jul;194(1):108-12. doi: 10.1097/00000658-198107000-00019.
A review of the microscope slides of the primary tumors for 596 patients with clinical Stage I melanoma revealed that primary lesions displayed two distinct patterns of invasion: 1) single cell invasion with direct extension of the main body of tumor into the reticular dermis or subcutaneous fat, and 2) invasion with "microscope satellites" (i.e. discrete tumor nests greater than 0.05 mm in diameter, that were separated from the main body of the tumor by normal reticular dermal collagen or subcutaneous fat). The five-year disease free survival rate for 95 patients with "microscopic satellites" was 36% +/- 6%. This is in contrast to a five-year disease free survival rate of 89% +/- 2% for 501 patients without these satellites (p = 4.3 x 10(-29), generalized Wilcoxon test). "Microscopic satellites" (present vs absent) was comparable to histologic ulceration in its additive prognostic effect of tumor thickness (Breslow).
对596例临床I期黑色素瘤患者的原发性肿瘤显微镜载玻片进行回顾后发现，原发性病变呈现出两种不同的浸润模式：1）单细胞浸润，肿瘤主体直接延伸至网状真皮或皮下脂肪；2）伴有“显微镜下卫星灶”的浸润（即直径大于0.05mm的离散肿瘤巢，被正常的网状真皮胶原或皮下脂肪与肿瘤主体分隔开）。95例有“显微镜下卫星灶”患者的五年无病生存率为36%±6%。这与501例无这些卫星灶患者89%±2%的五年无病生存率形成对比（p = 4.3×10⁻²⁹，广义Wilcoxon检验）。“显微镜下卫星灶”（存在与否）在对肿瘤厚度（Breslow）的附加预后影响方面与组织学溃疡相当。
