Day C L, Sober A J, Kopf A W, Lew R A, Mihm M C, Golomb F M, Hennessey P, Harris M N, Gumport S L, Raker J W, Malt R A, Cosimi A B, Wood W C, Roses D F, Gorstein F, Fitzpatrick T B, Postel A
Surgery. 1981 May;89(5):599-603.
Thirteen variables were studied to determine their usefulness in predicting recurrent disease in 158 patients with stage I melanoma of the lower extremity. A Cox proportional hazards analysis demonstrated that three variables were independent risk factors for recurrent disease in these patients: (1) thickness, in millimeters, of the primary tumor (P = 0.000009), (2) primary tumor location on the foot (P = 0.0003), and (3) the number of mitoses/mm2 (P = 0.0244). Life-table analyses of patient subgroups defined by different combinations of these three variables demonstrated that thick (greater than or equal to 3.0 mm) melanomas of the foot were associated with recurrent disease much more frequently than tumors of similar thickness located on the thigh or calf. These data provide guidelines that can be used to evaluate results of surgical and/or adjuvant therapy studies for patients with melanoma of the lower extremity.
研究了13个变量，以确定它们在预测158例下肢I期黑色素瘤患者疾病复发方面的效用。Cox比例风险分析表明，有三个变量是这些患者疾病复发的独立危险因素：（1）原发肿瘤的厚度（毫米）（P = 0.000009），（2）足部原发肿瘤位置（P = 0.0003），以及（3）每平方毫米的有丝分裂数（P = 0.0244）。对由这三个变量的不同组合定义的患者亚组进行的生存表分析表明，足部厚（大于或等于3.0毫米）的黑色素瘤比位于大腿或小腿的相似厚度肿瘤更常与疾病复发相关。这些数据提供了可用于评估下肢黑色素瘤患者手术和/或辅助治疗研究结果的指导原则。
