Crowley T J, Hydinger-Macdonald M
Arch Gen Psychiatry. 1981 Jun;38(6):668-75. doi: 10.1001/archpsyc.1981.01780310068007.
Clinical impressions suggest that thioridazine hydrochloride produces fewer extrapyramidal effects and more sedation than thiothixene. These drugs were given, each for three weeks, to 15 chronic schizophrenic outpatients in a counterbalanced, double-blind, crossover study. Spontaneous locomotion was recorded with an unobtrusive actometer toward the end of each three-week drug period. Surprisingly, patients were significantly more active with thioridazine, whereas parkinsonian scores, prolactin levels, and Brief Psychiatric Rating Scale scores remained about equal with the two drugs; thioridazine's extrapyramidal side effects were not "atypical." There are some explanations for why common clinical impressions and recent rodent studies have not predicted these results.
临床印象表明，与硫利达嗪相比，盐酸硫利达嗪产生的锥体外系效应更少，镇静作用更强。在一项平衡、双盲、交叉研究中，将这两种药物分别给予15名慢性精神分裂症门诊患者，每种药物服用三周。在每个为期三周的药物治疗期结束时，使用一种不显眼的活动计记录自发活动。令人惊讶的是，服用硫利达嗪的患者活动明显更多，而帕金森评分、催乳素水平和简明精神病评定量表评分在两种药物治疗下大致相同；硫利达嗪的锥体外系副作用并非“非典型”。对于为何常见的临床印象和近期的啮齿动物研究未能预测到这些结果，有一些解释。
