Bulfoni A, Geatti O, Gobbato F, Turrin D
Arch Sci Med (Torino). 1980 Oct-Dec;137(4):579-84.
Carcinoembryonic antigen (CEA), an oncofetal glycoprotein, has been originally suggested as a tumor marker for colorectal cancer and afterwards has been regarded as a specific marker for different cancers. The determination of CEA in 73 patients with "benign" hepatic diseases points out the limitation of test's diagnostic value on account of the not infrequent observation of false positives in the examined cases. In particular the greatest incidence and intensity of elevated levels of CEA has been found in hepatic cirrhosis. However must be mentioned that the highest values of CEA has been documented nearly constantly in the comparison's group of some forms of malignancies, between which nevertheless there have been sporadically false negatives.
癌胚抗原(CEA)是一种癌胚糖蛋白,最初被认为是结直肠癌的肿瘤标志物,后来被视为不同癌症的特异性标志物。对73例“良性”肝病患者进行CEA检测发现,由于在所检查的病例中经常观察到假阳性,该检测的诊断价值存在局限性。特别是在肝硬化患者中,CEA水平升高的发生率和强度最高。然而,必须指出的是,在某些恶性肿瘤的对照组中,CEA的最高值几乎一直都有记录,不过其间也偶尔会出现假阴性。