Bulfoni A
Arch Sci Med (Torino). 1981 Oct-Dec;138(4):449-54.
Carcinoembryonic antigen (CEA), a oncofetal glicoprotein, has been regarded as specific marker for colorectal cancer initially and restricted to the significance of tumor-associated antigen afterwards. Circulating CEA levels were determined in 47 patients with hematologic malignancies, resulting elevated in 10 (21%). The highest values had been discovered in a chronic lymphocitic leukemia complicated by primary hepatoma, causing the problem of the role played by the second tumor, likewise to another CEA-positive patient with the association "Hodgkin's disease-pancreatic carcinoma". The CEA employment had not been particularly satisfactory in the therapeutic monitoring and in the early detection of the relapses, in opposition to the results referred in the colorectal, mammary and bronchogenic carcinoma.
癌胚抗原(CEA)是一种癌胚糖蛋白,最初被视为结直肠癌的特异性标志物,后来其意义局限于肿瘤相关抗原。对47例血液系统恶性肿瘤患者测定了循环CEA水平,其中10例(21%)升高。在一例合并原发性肝癌的慢性淋巴细胞白血病患者中发现了最高值,这引发了第二种肿瘤所起作用的问题,另一例“霍奇金病-胰腺癌”关联的CEA阳性患者也是如此。与结直肠癌、乳腺癌和支气管癌的相关结果相反,CEA在治疗监测和复发早期检测中的应用并不特别令人满意。