Belendiuk K, Belendiuk G W, Freedman D X, Antel J P
Arch Neurol. 1981 Jul;38(7):415-7. doi: 10.1001/archneur.1981.00510070049006.
In 22 patients with motor neuron disease (MND), the mean concentration of serotonin (5HT) in platelets was slightly increased, platelet monoamine oxidase (MAO) activity was significantly increased, and plasma concentrations of total and both free and bound tryptophan were significantly decreased. Though platelet MAO activity was positively correlated with concentrations of 5HT, independent causal mechanisms are probable. When patients were rated according to severity, highest values of platelet 5HT and MAO activity were found in the most severely affected group, whereas concentrations of both total and protein-bound tryptophan were most decreased. Changes in concentrations of 5HT and tryptophan may reflect compensatory changes in response to degeneration of motor neurons or to interruption of their monoaminergic innervation.
在22例运动神经元病（MND）患者中，血小板中血清素（5HT）的平均浓度略有升高，血小板单胺氧化酶（MAO）活性显著升高，而血浆中总色氨酸以及游离和结合色氨酸的浓度均显著降低。虽然血小板MAO活性与5HT浓度呈正相关，但可能存在独立的因果机制。根据病情严重程度对患者进行评分时，发现血小板5HT和MAO活性的最高值出现在受影响最严重的组中，而总色氨酸和蛋白结合色氨酸的浓度下降最多。5HT和色氨酸浓度的变化可能反映了对运动神经元变性或其单胺能神经支配中断的代偿性变化。
