Wolf J W, White A A, Panjabi M M, Southwick W O
J Bone Joint Surg Am. 1981 Jun;63(5):805-10.
The strengths of healing long-bone fractures treated in two different mechanical environments were compared using a rabbit experimental model. Constant compression was applied to one healing tibial fracture, while the other was subjected to cyclic compression. At six weeks of healing, the group of tibial fractures treated with cyclic loading exhibited significantly higher torque and energy absorption to failure and lower stiffness than their pair-mates treated with constant compression. No statistically significant differences were detected at four or eight weeks of healing, although there was a suggestion that compression-treated bones may be stronger in the earlier phases of healing.
This experiment suggests that the requirements for rapid fracture-healing may vary with the stage of healing; that is, rigid immobilization applied during the initial stages of healing followed by intermittent compression during later stages.
使用兔实验模型比较了在两种不同力学环境中治疗的长骨骨折的愈合强度。对一侧愈合的胫骨骨折施加持续压缩，而另一侧则施加循环压缩。在愈合六周时，接受循环加载治疗的胫骨骨折组表现出明显更高的扭矩和能量吸收直至断裂，且刚度低于接受持续压缩治疗的配对组。在愈合四周或八周时未检测到统计学上的显著差异，尽管有迹象表明接受压缩治疗的骨骼在愈合早期可能更强壮。
该实验表明，快速骨折愈合的要求可能随愈合阶段而变化；也就是说，在愈合初期进行刚性固定，随后在后期进行间歇性压缩。
