Oakley D A
Behav Brain Res. 1981 Jul;3(1):55-69. doi: 10.1016/0166-4328(81)90028-0.
Normal rats and rats with 98.8% (S.D. +/- 1.4) of neocortex surgically removed were trained in a two-choice discrimination apparatus for food reward. The animals were first trained to run the apparatus with identical non-patterned goal box doors followed by discrimination and reversal training using horizontal and vertical striped panels attached to the doors. These patterned stimuli were matched for total luminous flux and contour length and control procedures were included for unintended discriminative cues from other sensory modalities. The two groups did not differ in the number of trials taken to complete preliminary training but the decorticates were significantly faster at running the apparatus than the normals. All animals solved the visual discrimination and were able to reverse it. There were no significant differences between the groups in trials taken to acquire the visual discrimination except at the very highest criterion levels employed, though reversal of the discrimination was more difficult for the lesioned group. The preliminary training data are taken as further evidence that total decortication does not necessarily impair instrumental performance for food reward and that this lesion does not introduce any limiting sensory or motor deficit in the alleyway situation. It would also appear that neocortex is not essential for the solution of a horizontal/vertical stripe problem. It is not clear, however, that such a solution necessarily depends on a true pattern discrimination, and both lesioned and normal animals may have been employing strategies based on local cues within the two patterned stimuli. The appropriateness of the total decorticate preparation for a resolution of the problem of cortical vs subcortical substrates of residual vision following visual cortex lesions is discussed. The possibility that undamaged neocortical tissue remaining after visual cortex lesions may inhibit the full expression of residual subcortical function is raised by these data.
正常大鼠和手术切除98.8%（标准差±1.4）新皮层的大鼠在双选辨别装置中接受食物奖励训练。动物首先接受训练，在目标箱门无图案且相同的情况下运行该装置，随后使用附着在门上的水平和垂直条纹面板进行辨别和反转训练。这些图案刺激在总光通量和轮廓长度上进行了匹配，并纳入了控制程序以排除来自其他感觉模态的意外辨别线索。两组在完成初步训练所需的试验次数上没有差异，但去皮质大鼠在运行该装置时比正常大鼠明显更快。所有动物都解决了视觉辨别问题并能够进行反转。除了在采用的最高标准水平外，两组在获得视觉辨别所需的试验次数上没有显著差异，不过对于损伤组来说，辨别反转更困难。初步训练数据进一步证明，完全去皮质不一定会损害食物奖励的工具性表现，并且这种损伤不会在通道情境中引入任何限制性的感觉或运动缺陷。似乎新皮层对于解决水平/垂直条纹问题也不是必不可少的。然而，尚不清楚这样的解决方法是否必然依赖于真正的图案辨别，并且损伤组和正常组动物可能都采用了基于两种图案刺激内局部线索的策略。讨论了完全去皮质准备对于解决视觉皮层损伤后残余视觉的皮层与皮层下基质问题的适用性。这些数据提出了视觉皮层损伤后残留的未受损新皮层组织可能抑制残余皮层下功能充分表达的可能性。
