胃肠道癌患者血浆中的肿瘤反应性IgE抗体。
Tumor-reactive IgE antibodies in plasma of patients with gastrointestinal carcinomas.
作者信息
Berczi I, Holford-Strevens V, Warsi Z H, McMorris L S, Thorlakson R H, Thorlakson T K, Sehon A H
出版信息
Cancer Immunol Immunother. 1983;14(3):180-4. doi: 10.1007/BF00205357.
A total of 208 plasma samples from 115 patients with gastrointestinal carcinomas and nine patients with other intestinal disease were examined for the presence of IgE tumor antibodies by a solid-phase radioimmunoassay. Approximately one-third of the patients gave significant reactions with gastrointestinal carcinoma extracts compared with normal tissue extracts. Absorption with tumor and normal tissue extracts, with type AB human red cells, and with CEA indicated tumor specificity in some of the samples so examined. None of the 50 serum samples tested from normal blood donors contained tumor-specific IgE. IgE tumor antibodies decreased or completely disappeared in the majority of patients 8-13 days after surgical treatment.
采用固相放射免疫分析法，对115例胃肠癌患者和9例其他肠道疾病患者的208份血浆样本进行检测，以寻找IgE肿瘤抗体。与正常组织提取物相比，约三分之一的患者对胃肠癌提取物产生明显反应。用肿瘤和正常组织提取物、AB型人红细胞以及癌胚抗原进行吸收试验，结果表明在所检测的部分样本中存在肿瘤特异性。50份正常献血者的血清样本中均未检测到肿瘤特异性IgE。大多数患者在手术治疗8 - 13天后，IgE肿瘤抗体减少或完全消失。
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