Tanner N S, Stamford I F, Bennett A
Br J Cancer. 1981 Jun;43(6):767-71. doi: 10.1038/bjc.1981.114.
Patients with head and neck cancer were treated with synchronous radiotherapy and chemotherapy (vincristine, bleomycin and methotrexate). Before treatment, mucositis was absent and low amounts of prostaglandin-like material were extracted from peripheral plasma. As treatment proceeded mucositis occurred, and its degree correlated with the amount of prostaglandin-like material extracted from the plasma. Some patients were given moderate doses of drugs which inhibit prostaglandin synthesis, but mucositis still occurred.
头颈部癌患者接受同步放化疗（长春新碱、博来霉素和甲氨蝶呤）治疗。治疗前，患者无口腔黏膜炎，外周血浆中提取出的前列腺素样物质含量较低。随着治疗的进行，口腔黏膜炎出现，其严重程度与血浆中提取出的前列腺素样物质的量相关。部分患者给予了中等剂量的抑制前列腺素合成的药物，但口腔黏膜炎仍会出现。
