Mulder H, Hackeng W H, Silberbusch J, den Ottolander G J, van der Meer C
Br J Cancer. 1981 Jun;43(6):786-92. doi: 10.1038/bjc.1981.116.
In 132 consecutive patients with carcinoma of various organs, a higher serum immunoreactive calcitonin (ICT) concentration (median level 50 pg/ml) was found than in 68 normal subjects (median level 20 pg/ml). The incidence of hypercalcitoninaemia was 40%. All 9 patients with primary liver-cell carcinoma were hypercalcitoninaemic. On the other hand, none of the 7 patients with a carcinoma of the breast had raised ICT levels. In bronchogenic cancer a relationship between ICT and cell type was found, with a predominance of high ICT in patients with oatcell and other undifferentiated types, whereas in squamous-cell carcinomas and adenocarcinomas of the lung hypercalcitoninaemia was relatively rare. When we divided all our patients according to differentiation of the tumour cell, it was found that the lower the degree of differentiation, the higher the ICT concentration, whereas opposite results were observed for CEA. When ICT and CEA were estimated concurrently, we found at least one marker increased in 70% of our patients. Our results demonstrate that patients with metastases in the liver have more frequently and increased ICT. In addition, we conclude that lifespan can be expected to be lower in patients with high ICT levels. In a longitudinal study of 46 patients, there was a positive correlation between change in serum ICT and tumour mass.
在132例患有各种器官癌的患者中，发现血清免疫反应性降钙素（ICT）浓度较高（中位水平为50 pg/ml），高于68名正常受试者（中位水平为20 pg/ml）。高降钙素血症的发生率为40%。所有9例原发性肝细胞癌患者均有高降钙素血症。另一方面，7例乳腺癌患者中无一例ICT水平升高。在支气管源性癌中，发现ICT与细胞类型之间存在关联，燕麦细胞癌和其他未分化类型的患者中高ICT占优势，而在肺鳞状细胞癌和腺癌中，高降钙素血症相对少见。当我们根据肿瘤细胞的分化程度对所有患者进行分类时，发现分化程度越低，ICT浓度越高，而癌胚抗原（CEA）则呈现相反的结果。当同时检测ICT和CEA时，我们发现70%的患者至少有一项标志物升高。我们的结果表明，肝转移患者的ICT更频繁且升高。此外，我们得出结论，ICT水平高的患者预期寿命可能较短。在对46例患者的纵向研究中，血清ICT的变化与肿瘤大小呈正相关。
