Chailley B, Giraud F, Claret M
Biochim Biophys Acta. 1981 May 20;643(3):636-41. doi: 10.1016/0005-2736(81)90359-x.
Cholesterol depletion of erythrocytes, obtained after incubation with phosphatidylcholine vesicles, induces in most of the experiments: (1) a discocytestomatocyte transformation as observed by scanning electron microscopy; (2) a specific decrease in spectrin phosphorylation of intact erythrocytes; (3) an increase in lipid phosphorylation. It is concluded that the effect of cholesterol on erythrocyte shape is probably mediated through its action on the activity o of membrane-bound enzymes, proteases or kinases.
用磷脂酰胆碱囊泡孵育后获得的红细胞胆固醇耗竭，在大多数实验中会引发：（1）通过扫描电子显微镜观察到的盘状红细胞向口形红细胞的转变；（2）完整红细胞中血影蛋白磷酸化的特异性降低；（3）脂质磷酸化增加。得出的结论是，胆固醇对红细胞形状的影响可能是通过其对膜结合酶、蛋白酶或激酶活性的作用来介导的。
