• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mechanism of anti-inflammatory action of glucocorticoids: re-evaluation of vascular constriction hypothesis.糖皮质激素的抗炎作用机制：血管收缩假说的重新评估
Br J Pharmacol. 1981 Jul;73(3):605-8. doi: 10.1111/j.1476-5381.1981.tb16794.x.
2
Comparative study between steroidal and nonsteroidal anti-inflammatory drugs on the mode of their actions on vascular permeability in rat carrageenin-air-pouch inflammation.甾体类与非甾体类抗炎药对大鼠角叉菜胶气囊炎症血管通透性作用方式的比较研究
J Pharmacobiodyn. 1980 Jul;3(7):345-52. doi: 10.1248/bpb1978.3.345.
3
Effect of glucocorticoids on vascular reactivity to vasoactive hormones in rat isolated kidney: lack of relationship to prostaglandins.糖皮质激素对大鼠离体肾脏血管对血管活性激素反应性的影响：与前列腺素无关。
Br J Pharmacol. 1984 Jul;82(3):679-88. doi: 10.1111/j.1476-5381.1984.tb10807.x.
4
[Simultaneous measurements of anti-exudation and anti-granulation activities of anti-inflammatory steroids].[抗炎类固醇的抗渗出和抗肉芽形成活性的同步测量]
Nihon Yakurigaku Zasshi. 1970 May 20;66(3):316-25. doi: 10.1254/fpj.66.316.
5
Differences in the mode of exucative reaction between early phase and late phase of carrageenin-induced inflammation in rats.角叉菜胶诱导的大鼠炎症早期和晚期执行反应模式的差异。
Eur J Pharmacol. 1976 Mar;36(1):7-14. doi: 10.1016/0014-2999(76)90250-8.
6
Hepatic drug-metabolizing enzyme activities and anti-inflammatory potency of hydrocortisone in rats with granulomatous inflammation.氢化可的松在肉芽肿性炎症大鼠中的肝药物代谢酶活性及抗炎效力
Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):195-206.
7
Relationship between the anti-phospholipase and anti-inflammatory effects of glucocorticoid-induced proteins.糖皮质激素诱导蛋白的抗磷脂酶作用与抗炎作用之间的关系。
Eur J Pharmacol. 1984 Mar 23;99(2-3):233-9. doi: 10.1016/0014-2999(84)90246-2.
8
Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertension.原发性高血压中血管收缩剂对糖皮质激素的敏感性增加。
Hypertension. 1996 Feb;27(2):190-6. doi: 10.1161/01.hyp.27.2.190.
9
Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants.血管抑制性类固醇和地塞米松对大鼠海绵植入物中血管生成和细胞因子水平的不同影响。
Br J Pharmacol. 1996 Aug;118(7):1584-91. doi: 10.1111/j.1476-5381.1996.tb15578.x.
10
The characteristic feature of glucocorticoids after local application with reference to leucocyte migration and protein exudation.局部应用糖皮质激素后在白细胞迁移和蛋白质渗出方面的特征。
Eur J Pharmacol. 1969 Aug;7(2):201-5. doi: 10.1016/0014-2999(69)90011-9.

引用本文的文献

1
Induction of hypoglycaemia and accumulation of 5-hydroxytryptamine in the liver after the injection of mitogenic substances into mice.向小鼠注射促有丝分裂物质后肝脏中低血糖的诱导及5-羟色胺的积累。
Br J Pharmacol. 1984 Apr;81(4):645-50. doi: 10.1111/j.1476-5381.1984.tb16130.x.

本文引用的文献

1
Studies on the permeability of connective tissue. I. The effects of dibenamine on the decreased dermal spread caused by intraarticular burns, corticotropine, posterior pituitary extract, adrenaline and noradrenaline.结缔组织通透性的研究。I. 二苯胺对关节内烧伤、促肾上腺皮质激素、垂体后叶提取物、肾上腺素和去甲肾上腺素所致皮肤扩散减少的影响。
Acta Pharmacol Toxicol (Copenh). 1954;10(4):390-400. doi: 10.1111/j.1600-0773.1954.tb01355.x.
2
HISTAMINE AND AUTONOMOUS RESPONSES OF THE MICROCIRCULATION; RELATIONSHIP TO GLUCOCORTICOID ACTION.组胺与微循环的自主反应；与糖皮质激素作用的关系。
Ann N Y Acad Sci. 1964 Aug 27;116:891-8. doi: 10.1111/j.1749-6632.1964.tb52555.x.
3
VASOACTIVE AMINES IN ACUTE INFLAMMATION.急性炎症中的血管活性胺
Ann N Y Acad Sci. 1964 Aug 27;116:839-46. doi: 10.1111/j.1749-6632.1964.tb52549.x.
4
ACTION OF PROSTAGLANDIN E1 ON TISSUES WHICH RESPOND TO BRADYKININ.前列腺素E1对缓激肽反应性组织的作用
Nature. 1963 Nov 30;200:892-3. doi: 10.1038/200892b0.
5
Observations on the effects of infusion of prostaglandin E in man.关于前列腺素E输注对人体影响的观察
Acta Physiol Scand. 1959 Mar 31;45:145-51. doi: 10.1111/j.1748-1716.1959.tb01686.x.
6
A rapid method for preparing washed red cells tagged with chromium 51.一种制备51铬标记洗涤红细胞的快速方法。
J Lab Clin Med. 1959 Aug;54:300-3.
7
The effect of locally injected anti-inflammatory drugs on the carrageenin granuloma in rats.局部注射抗炎药物对大鼠角叉菜胶肉芽肿的影响。
Biochem Pharmacol. 1969 Feb;18(2):475-84. doi: 10.1016/0006-2952(69)90223-8.
8
The anti-inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse.儿茶酚胺在小鼠腹腔和后爪的抗炎作用。
Br J Pharmacol. 1972 Jun;45(2):322-32. doi: 10.1111/j.1476-5381.1972.tb08086.x.
9
Topical corticosteroids--an experimental evaluation of the vasoconstrictor test as an index of anti-inflammatory activity.局部用皮质类固醇——血管收缩试验作为抗炎活性指标的实验评估
Br J Dermatol. 1968 May;80(5):328-36. doi: 10.1111/j.1365-2133.1968.tb12307.x.
10
Assay of topical corticosteroids by suppression of experimental inflammation in humans.通过抑制人体实验性炎症来测定局部用皮质类固醇。
J Invest Dermatol. 1974 Sep;63(3):292-7. doi: 10.1111/1523-1747.ep12680178.

糖皮质激素的抗炎作用机制：血管收缩假说的重新评估

Mechanism of anti-inflammatory action of glucocorticoids: re-evaluation of vascular constriction hypothesis.

作者信息

Sugio K, Tsurufuji S

出版信息

Br J Pharmacol. 1981 Jul;73(3):605-8. doi: 10.1111/j.1476-5381.1981.tb16794.x.

DOI:10.1111/j.1476-5381.1981.tb16794.x
PMID:7248660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071708/
Abstract

1 The question whether constriction of local vessels is essential for the anti-inflammatory action of glucocorticoids in carrageenin-induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E1 injection into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma tissue. 3 Noradrenaline significantly reduced plasma exudation, possibly through alpha-adrenoceptor stimulation. 4 Cortisol and dexamethasone in doses sufficient to inhibit vascular permeability were without effect on the blood content in the granuloma tissue. 5 The results suggest that constriction of local vessels does not play an essential role in the anti-exudative effect of glucocorticoids in chronic proliferation inflammation.

摘要
  1. 研究了局部血管收缩对于糖皮质激素在角叉菜胶诱导的肉芽肿性炎症中抗炎作用是否必不可少这一问题。2. 向肉芽肿囊袋液中注射血管舒张剂前列腺素E1会增加血浆蛋白向肉芽肿组织的渗出。3. 去甲肾上腺素可能通过刺激α-肾上腺素受体显著减少血浆渗出。4. 足以抑制血管通透性的剂量的皮质醇和地塞米松对肉芽肿组织中的血液含量没有影响。5. 结果表明，局部血管收缩在糖皮质激素对慢性增殖性炎症的抗渗出作用中不起重要作用。