多巴胺部分介导脊髓损伤后纳洛酮的心血管效应。
Dopamine partially mediates the cardiovascular effects of naloxone after spinal injury.
作者信息
Faden A I, Jacobs T P, Feuerstein G, Holaday J W
出版信息
Brain Res. 1981 Jun 1;213(2):415-21. doi: 10.1016/0006-8993(81)90246-8.
PMID:7248764
Abstract
Following spinal injury, the opiate antagonist naloxone selectively elevates plasma dopamine levels, with the dopamine changes significantly correlated with improved cardiovascular function. Moreover, the cardiovascular effects of naloxone are significantly attenuated by pretreatment with the dopamine antagonist domperidone. From these data, it is concluded that the cardiovascular effects of naloxone after spinal injury are in part dopamine mediated.
摘要
脊髓损伤后，阿片类拮抗剂纳洛酮可选择性升高血浆多巴胺水平，多巴胺的变化与心血管功能改善显著相关。此外，多巴胺拮抗剂多潘立酮预处理可显著减弱纳洛酮的心血管效应。从这些数据得出结论，脊髓损伤后纳洛酮的心血管效应部分由多巴胺介导。
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