Herve D, Simon H, Blanc G, Lemoal M, Glowinski J, Tassin J P
Brain Res. 1981 Jul 20;216(2):422-8. doi: 10.1016/0006-8993(81)90144-x.
As revealed by the changes in dihydroxyphenylacetic acid (DOPAC) levels and in the DOPAC/Dopamine (DA) ratio, DA utilization was markedly enhanced in the nucleus accumbens and reduced in the prefrontal cortex of rats five days after the electrolytic lesions of the median raphe. These opposite effects were not seen any more seventeen days after the injection. These results suggest that neurones originating from the median raphe and projecting to the ventral tegmental area exert an opposite effect on the activity of DA cells innervating the nucleus accumbens and on those projecting to the prefrontal cortex.
正如二羟基苯乙酸（DOPAC）水平及DOPAC/多巴胺（DA）比值的变化所显示的那样，在中缝正中进行电解损伤五天后，大鼠伏隔核中的DA利用率显著提高，而前额叶皮质中的DA利用率则降低。注射十七天后不再出现这些相反的效应。这些结果表明，起源于中缝正中并投射至腹侧被盖区的神经元，对支配伏隔核的DA细胞的活性以及对投射至前额叶皮质的DA细胞的活性产生相反的作用。
