Ostrow S, Diggs C H, Sutherland J, Wiernik P H
Cancer. 1981 Aug 1;48(3):779-82. doi: 10.1002/1097-0142(19810801)48:3<779::aid-cncr2820480320>3.0.co;2-3.
The causes of death and postmortem findings in patients treated for non-Hodgkin's lymphoma at a single institution over a 13-year period were reviewed. Postmortem examination (70% of the entire sample) revealed evidence of lymphoma in 67 of 80 patients. The most frequent extranodal sites of involvement were the respiratory tract, bone marrow, liver, kidney, and gastrointestinal tract in that order. The most common cause of death was infection (33% of cases). Predisposing factors for infection included the underlying disease, (i.e., lymphomatous infiltration of organ systems) and granulocytopenia secondary to combination chemotherapy. Other causes of death included hemorrhage and respiratory failure secondary to lymphomatous infiltration of the lung. Despite advances in therapy and supportive care of patients with non-Hodgkin's lymphoma, many patients still die of this disease or of sequelae related to its treatment.
回顾了某单一机构在13年期间治疗的非霍奇金淋巴瘤患者的死亡原因和尸检结果。尸检（占整个样本的70%）显示，80例患者中有67例存在淋巴瘤证据。最常受累的结外部位依次为呼吸道、骨髓、肝脏、肾脏和胃肠道。最常见的死亡原因是感染（占病例的33%）。感染的诱发因素包括基础疾病（即器官系统的淋巴瘤浸润）和联合化疗继发的粒细胞减少。其他死亡原因包括出血和肺部淋巴瘤浸润继发的呼吸衰竭。尽管在非霍奇金淋巴瘤患者的治疗和支持治疗方面取得了进展，但许多患者仍死于这种疾病或与其治疗相关的后遗症。
