Feld R, Bodey G P
Cancer. 1977 Mar;39(3):1018-25. doi: 10.1002/1097-0142(197703)39:3<1018::aid-cncr2820390304>3.0.co;2-n.
The records of 360 patients with malignant lymphoma treated with various forms of combination chemotherapy from 1966 to 1974 were reviewed. A total of 181 infections was found in 125 patients. The most frequent types of infection were pneumonia (31%), skin infections (17%), urinary tract infections (13%) and septicemia (11%). An etiologic organism was was identified in 133 infections (73%). The most common causative organisms were bacteria (77%), especially gram-negative bacilli. Viral infections accounted for 18% of the infections with 21 of the 24 being due to herpes zoster. These were more frequently found in patients with Hodgkin's disease (14/21) than in the other lymphomas. Among patients with Hodgkin's disease, 53% treated with COP developed infections compared to only 27% treated with MOPP (p = 0.039). Among patients with non-Hodgkin's lymphoma, infections were more frequent in patients treated with Adriamycin containing combinations than with COP. Neutropenia (i.e. less than 1,000 neutrophils/mm3) was associated with 35% of infections in this study and was seen more often in patients with non-Hodgkin's lymphoma (p = 0.048).
回顾了1966年至1974年间接受各种联合化疗的360例恶性淋巴瘤患者的记录。在125例患者中总共发现了181次感染。最常见的感染类型为肺炎（31%）、皮肤感染（17%）、尿路感染（13%）和败血症（11%）。133次感染（73%）中确定了病原体。最常见的病原体是细菌（77%），尤其是革兰氏阴性杆菌。病毒感染占感染的18%，24次中有21次是由带状疱疹引起。这些在霍奇金病患者中（14/21）比在其他淋巴瘤患者中更常见。在霍奇金病患者中，接受COP治疗的患者有53%发生感染，而接受MOPP治疗的仅为27%（p = 0.039）。在非霍奇金淋巴瘤患者中，接受含阿霉素联合治疗的患者比接受COP治疗的患者感染更频繁。在本研究中，中性粒细胞减少（即中性粒细胞少于1000/mm³）与35%的感染有关，在非霍奇金淋巴瘤患者中更常见（p = 0.048）。
