Bakale G, McCreary R D, Gregg E C
Cancer Biochem Biophys. 1981;5(2):103-9.
The quasifree electron attachment rate constant, kappa e, was measured in liquid cyclohexane at 20 degrees C for 76 chemicals that had been tested for bacterial mutagenicity in at least one of five earlier studies designed to determine the correlation between bacterial mutagenicity and animal carcinogenicity. A millionfold range of kappa e's was observed with the kappa e of 37 of 42 carcinogens being equal to or greater than the diffusion-controlled electron attachment rate constant, kappa d, of 2.9 x 10(12) M-1 s-1, whereas kappa e was less than kappa d for 30 of 34 noncarcinogens. These results yield a sensitivity of 88 percent for kappa e greater than or equal to kappa d indicating a chemical's carcinogenicity and a specificity also of 88% for kappa less than kappa d indicating a noncarcinogenic chemical. The observed quasifree electron attachment sensitivity and specificity compare favorably with previously observed Ames-test mutagenicity/carcinogenicity correlations which suggests that kappa e measurements also may be of value in a carcinogen-screening program.
在20℃的液态环己烷中，测量了76种化学物质的准自由电子附着速率常数κe。这些化学物质在之前五项旨在确定细菌致突变性与动物致癌性之间相关性的研究中的至少一项中，已接受过细菌致突变性测试。观察到κe的范围跨越了一百万倍，42种致癌物中的37种的κe等于或大于扩散控制的电子附着速率常数κd，即2.9×10¹² M⁻¹ s⁻¹，而34种非致癌物中的30种的κe小于κd。这些结果表明，对于κe大于或等于κd表明化学物质具有致癌性的情况，敏感性为88%；对于κ小于κd表明化学物质不具有致癌性的情况，特异性也为88%。观察到的准自由电子附着敏感性和特异性与之前观察到的艾姆斯试验致突变性/致癌性相关性相比具有优势，这表明κe测量在致癌物筛选程序中也可能具有价值。
