Catanese B, Facchini V, Barillari G, Putzolu S
Clin Exp Obstet Gynecol. 1980;7(2):84-8.
The serum levels of benzydamine were studied after administration by vaginal douching (at a concentration of 0.0%) to patients with and without vaginal inflammation. In both experimental groups benzydamine produced similar serum concentrations which were lower than those obtained by other administration routes, excluding the possibillity of eventual systemic effects. These data are a further confirmation that, whenever possible, topical use is preferable to systemic use in order to reduce the incidence of systemic side effects to a minimum and to obtain a more selective therapy.
通过阴道灌洗（浓度为0.0%）对有或无阴道炎症的患者给药后，研究了苄达明的血清水平。在两个实验组中，苄达明产生的血清浓度相似，且低于通过其他给药途径获得的浓度，排除了可能产生全身效应的可能性。这些数据进一步证实，只要有可能，局部用药优于全身用药，以便将全身副作用的发生率降至最低，并获得更具选择性的治疗。
