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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chiba S, Watanabe H, Furukawa Y

Clin Exp Pharmacol Physiol. 1981 Mar-Apr;8(2):171-4. doi: 10.1111/j.1440-1681.1981.tb00148.x.

The inotropic effects of inosine, adenosine and guanosine were compared in isolated and blood-perfused canine atrial and ventricular muscle preparations paced at 1.5-2.5 Hz. 2. In isolated atria, guanosine and inosine usually had positive inotropic effects, but adenosine consistently had a marked negative inotropic effect. 3. In ventricular muscles, the three purine compounds examined produced dose-related positive inotropic responses, but adenosine also produced a slight negative inotropic response which preceded the positive inotropic response.

在以1.5 - 2.5Hz起搏的离体和血液灌注的犬心房和心室肌制备物中，比较了肌苷、腺苷和鸟苷的变力作用。2. 在离体心房中，鸟苷和肌苷通常具有正性变力作用，但腺苷始终具有明显的负性变力作用。3. 在心室肌中，所检测的三种嘌呤化合物产生剂量相关的正性变力反应，但腺苷也产生轻微的负性变力反应，该反应先于正性变力反应出现。

Chiba S, Watanabe H, Furukawa Y

Clin Exp Pharmacol Physiol. 1981 Mar-Apr;8(2):171-4. doi: 10.1111/j.1440-1681.1981.tb00148.x.

The inotropic effects of inosine, adenosine and guanosine were compared in isolated and blood-perfused canine atrial and ventricular muscle preparations paced at 1.5-2.5 Hz. 2. In isolated atria, guanosine and inosine usually had positive inotropic effects, but adenosine consistently had a marked negative inotropic effect. 3. In ventricular muscles, the three purine compounds examined produced dose-related positive inotropic responses, but adenosine also produced a slight negative inotropic response which preceded the positive inotropic response.

在以1.5 - 2.5Hz起搏的离体和血液灌注的犬心房和心室肌制备物中，比较了肌苷、腺苷和鸟苷的变力作用。2. 在离体心房中，鸟苷和肌苷通常具有正性变力作用，但腺苷始终具有明显的负性变力作用。3. 在心室肌中，所检测的三种嘌呤化合物产生剂量相关的正性变力反应，但腺苷也产生轻微的负性变力反应，该反应先于正性变力反应出现。