联合缺血和酸中毒对灌注大鼠肝脏乳酸摄取和糖异生的影响。

The effect of combined ischaemia and acidosis on lactate uptake and gluconeogenesis in the perfused rat liver.

Iles R A, Cohen R D, Baron P G

Clin Sci (Lond). 1981 May;60(5):537-42. doi: 10.1042/cs0600537.

Abstract

Perfused rat livers were subjected to an acid perfusate and varying degrees of ischaemia in an attempt to simulate the conditions of strenuous exercise or shock. 2. Lactate uptake and glucose output from the liver decreased during moderate ischaemia alone and more so when, in addition, the perfusate was made acidic. 3. Hepatic ATP and ADP content increased in the presence of an acid perfusate. 4. It is concluded that both ischaemia and acidosis may contribute to the diminished hepatic uptake of lactic acid in strenuous exercise and shock.

摘要

对灌注的大鼠肝脏施加酸性灌注液并使其处于不同程度的缺血状态，以试图模拟剧烈运动或休克的情况。2. 仅在中度缺血期间，肝脏对乳酸的摄取和葡萄糖输出就会减少，而当灌注液变为酸性时，这种减少更为明显。3. 在酸性灌注液存在的情况下，肝脏中的三磷酸腺苷（ATP）和二磷酸腺苷（ADP）含量增加。4. 得出的结论是，缺血和酸中毒都可能导致在剧烈运动和休克时肝脏对乳酸的摄取减少。