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大鼠庆大霉素诱导的肾毒性中的尿里甘蛋白和谷胱甘肽 - S - 转移酶

Urinary ligandin and glutathione-S-transferase in gentamicin-induced nephrotoxicity in the rat.

作者信息

Feinfeld D A, Fleischner G M, Arias I M

出版信息

Clin Sci (Lond). 1981 Jul;61(1):123-5. doi: 10.1042/cs0610123.

DOI:10.1042/cs0610123
PMID:7249552
Abstract
  1. Eight rats developed detectable glutathione-S-transferase activity in their urine after three daily injections of toxic doses of gentamicin. 2. Seven of the eight rats had immunodetectable ligandin in their urine at this time. 3. The level of enzyme activity correlated well with the degree of elevation of serum creatinine. 4. This confirms ligandinuria and urinary glutathione-S-transferase as markers of acute renal proximal tubular injury.
摘要
  1. 八只大鼠在每日注射三次毒性剂量的庆大霉素后，其尿液中出现了可检测到的谷胱甘肽-S-转移酶活性。2. 此时，这八只大鼠中有七只尿液中存在免疫可检测的配体蛋白。3. 酶活性水平与血清肌酐升高程度密切相关。4. 这证实了尿配体蛋白和尿谷胱甘肽-S-转移酶可作为急性肾近端小管损伤的标志物。

相似文献

1
Urinary ligandin and glutathione-S-transferase in gentamicin-induced nephrotoxicity in the rat.大鼠庆大霉素诱导的肾毒性中的尿里甘蛋白和谷胱甘肽 - S - 转移酶
Clin Sci (Lond). 1981 Jul;61(1):123-5. doi: 10.1042/cs0610123.
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Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat.大鼠顺铂肾毒性中的尿谷胱甘肽-S-转移酶
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Inhibitory effect of olive leaf extract on gentamicin-induced nephrotoxicity in rats.橄榄叶提取物对庆大霉素诱导的大鼠肾毒性的抑制作用。
Iran J Kidney Dis. 2012 Jan;6(1):25-32.
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Ligandinuria: an indication of tubular cell necrosis.配体尿症：肾小管细胞坏死的一种指征。
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Effect of fish oil treatment on gentamicin nephrotoxicity in rats.鱼油治疗对大鼠庆大霉素肾毒性的影响。
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Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat.两种雄性大鼠化学诱导肾毒性生物标志物的生物学特征鉴定。
Toxicol Sci. 2011 Aug;122(2):235-52. doi: 10.1093/toxsci/kfr112. Epub 2011 May 18.
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Ligandinuria in nephrotoxic acute tubular necrosis.
Kidney Int. 1977 Dec;12(6):387-92. doi: 10.1038/ki.1977.129.
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Determination of urinary glutathione S-transferase and lactate dehydrogenase for differentiation between proximal and distal nephron damage.测定尿谷胱甘肽S-转移酶和乳酸脱氢酶以鉴别近端和远端肾单位损伤。
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Urinary ligandin in renal tubular cell injury.肾小管细胞损伤中的尿里甘蛋白
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Gentamicin nephrotoxicity in rat: some biochemical correlates.庆大霉素对大鼠的肾毒性：一些生化关联
Pharmacol Toxicol. 1992 Jun;70(6 Pt 1):419-23. doi: 10.1111/j.1600-0773.1992.tb00500.x.

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Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion.健康足月新生儿尿中肾生物标志物浓度：GST-pi 排泄的性别差异。
Med Sci Monit. 2024 Feb 23;30:e942819. doi: 10.12659/MSM.942819.
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Urinary π-glutathione S-transferase Predicts Advanced Acute Kidney Injury Following Cardiovascular Surgery.尿π-谷胱甘肽S-转移酶可预测心血管手术后的严重急性肾损伤。
Sci Rep. 2016 Aug 16;6:26335. doi: 10.1038/srep26335.
3
Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development.
用于临床药物研发中早期检测肾毒性的尿液肾脏生物标志物。
Br J Clin Pharmacol. 2014 Jun;77(6):947-57. doi: 10.1111/bcp.12282.
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Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and beta-methylcholanthrene.苯巴比妥和β-甲基胆蒽应激下大鼠脑和睾丸谷胱甘肽转移酶的比较研究
J Zhejiang Univ Sci B. 2005 Aug;6(8):759-69. doi: 10.1631/jzus.2005.B0759.
5
Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury.谷胱甘肽S-转移酶同工酶在人肾中的分布：肾损伤潜在标志物的基础
J Clin Pathol. 1989 Jun;42(6):624-8. doi: 10.1136/jcp.42.6.624.
6
Determination of urinary glutathione S-transferase and lactate dehydrogenase for differentiation between proximal and distal nephron damage.测定尿谷胱甘肽S-转移酶和乳酸脱氢酶以鉴别近端和远端肾单位损伤。
Arch Toxicol. 1990;64(4):269-78. doi: 10.1007/BF01972986.