使用手持可编程计算器进行药代动力学研究中的面积估计。
Area estimation in pharmacokinetic studies using a hand-held programmable calculator.
作者信息
Bury R W
出版信息
Int J Biomed Comput. 1984 May-Jun;15(3):219-24. doi: 10.1016/0020-7101(84)90055-2.
PMID:6735513
Abstract
A short program for area analysis in pharmacokinetic studies using the Hewlett-Packard HP41C hand-held programmable calculator is described. Area under the concentration-time curve is calculated firstly within defined time limits and then with extrapolation to infinite time using the slope constant of the terminal phase. Input of concentration-time data is simple and there is no limit on the number of time-concentration co-ordinates which can be entered for area calculation.
摘要
本文描述了一个使用惠普HP41C手持可编程计算器进行药代动力学研究中面积分析的简短程序。首先在规定的时间范围内计算浓度-时间曲线下的面积，然后使用终末相的斜率常数外推至无限时间。浓度-时间数据的输入很简单，并且对于用于面积计算的时间-浓度坐标数量没有限制。
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