Lateva E, Cherkezova E, Balutsov M
Eksp Med Morfol. 1981;20(2):108-12.
The authors carried out studies on 16 rabbits - 10 experimental and 6 control with implanted duodenal fistula. They poured for a period of 4 days through the fistula the duodenal content of 6 sick persons with acute and chronic relapsing pancreatitis into the duodenum of the experimental animals and the content of 2 healthy persons-to the animals of the control group. After each pouring the activity of pancreatic and intestinal enzymes was determined in sera and duodenal contents of the rabbits. The duodenum, pancreas, liver and kidneys were examined histomorphologically after killing the experimental animals. The obtained results showed that there were no changes in the enzyme activity and morphologic picture of the organs after pouring duodenal content of healthy persons. The enzyme activity was reduced in the duodenal content of the experimental animals, but in the sera was increased. Pancreatitis, duodenitis, fatty dystrophy of liver and parenchymatous dystrophy of kidneys was established histomorphologically. The authors suggest the appearance of some toxic substances in the duodenal content of sick persons with acute and chronic relapsing pancreatitis.
作者对16只兔子进行了研究，其中10只为实验组，6只为对照组，均植入十二指肠瘘管。他们在4天的时间里，将6例急性和慢性复发性胰腺炎患者的十二指肠内容物通过瘘管注入实验组动物的十二指肠，将2例健康人的十二指肠内容物注入对照组动物的十二指肠。每次注入后，测定兔子血清和十二指肠内容物中胰腺和肠道酶的活性。在处死实验动物后，对十二指肠、胰腺、肝脏和肾脏进行组织形态学检查。结果表明，注入健康人的十二指肠内容物后，器官的酶活性和形态学图像没有变化。实验组动物十二指肠内容物中的酶活性降低，但血清中的酶活性增加。组织形态学检查发现有胰腺炎、十二指肠炎症、肝脏脂肪变性和肾实质变性。作者认为，急性和慢性复发性胰腺炎患者的十二指肠内容物中出现了一些有毒物质。
