在CBA小鼠中，腺病毒12诱导的可移植肿瘤生长过程中免疫反应性的变化。
Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice.
作者信息
Britten V, Underwood J C
出版信息
Experientia. 1981 May 15;37(5):504-5. doi: 10.1007/BF01986164.
PMID:7250325
Abstract
Early suppression, followed by a period of enhancement and finally, suppression, was seen when the spleen cell response to T and B cell mitogens was monitored during growth of an adenovirus 12-induced tumour in CBA black mice. The macrophage content of the tumour changed with time and these fluctuations correlated with the ability of tumour tissue extracts to enhance the normal spleen cell response to mitogen.
摘要
在CBA黑小鼠中监测腺病毒12诱导的肿瘤生长过程中，当观察脾细胞对T细胞和B细胞有丝分裂原的反应时，发现先是早期抑制，接着是一段时间的增强，最后又是抑制。肿瘤中的巨噬细胞含量随时间变化，这些波动与肿瘤组织提取物增强正常脾细胞对有丝分裂原反应的能力相关。
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