Sheskin J, Gorodetzky R, Loewinger E, Weinreb A
Dermatologica. 1981;162(2):86-90. doi: 10.1159/000250254.
The concentration of iron, cooper and zinc in the skin of patients with prurigo nodularis was measured by diagnostic X-ray spectrometry before and after treatment with thalidomide. Before treatment, larger skin lesions were associated with significantly higher zinc levels and higher iron levels than the smaller ones. Upon treatment the zinc and iron content in these lesions decreased towards normal range. Copper values were found to be within the normal range in lesions before and after thalidomide treatment.
采用诊断性X射线光谱法测定了结节性痒疹患者治疗前后皮肤中铁、铜和锌的浓度。治疗前，较大的皮肤损害与较小的皮肤损害相比，锌水平和铁水平显著更高。治疗后，这些损害中的锌和铁含量降至正常范围。发现沙利度胺治疗前后损害中的铜值均在正常范围内。
