Sheskin J, Gorodetsky R, Weinreb A, Loewinger E
Dermatologica. 1981;163(2):145-50. doi: 10.1159/000250151.
THe concentration of copper, zinc and iron in the skin of patients suffering from lepra reaction was measured by diagnostic X-ray spectrometry (DXS) at the sites of the lesions before and after treatment with thalidomide. The results were compared with the levels of these elements in the skin of healthy individuals. No significant changes in the copper level of leprous skin were found. The zinc levels showed significant elevations in some lesions with no apparent trend. The iron level in the affected areas had highly elevated values in all cases of lepra reaction. However, in contrast to the fast clinical improvement which followed the treatment with thalidomide, the iron levels did not decrease for prolonged periods.
采用诊断X射线光谱法（DXS）测定了沙利度胺治疗前后麻风反应患者皮损部位铜、锌和铁的浓度。将结果与健康个体皮肤中这些元素的水平进行比较。麻风皮肤的铜水平未发现明显变化。锌水平在一些皮损中有显著升高，但无明显趋势。在所有麻风反应病例中，受累区域的铁水平均显著升高。然而，与沙利度胺治疗后临床症状迅速改善形成对比的是，铁水平在较长时间内并未下降。
