Lichtig C, Haim S, Gilhar A, Hammel I, Ludatscher R
Dermatologica. 1981;162(3):167-74. doi: 10.1159/000250265.
In order to assess the role of mast cells in the pathogenesis of mucocutaneous lesions of Behçet's disease, the following investigations were performed: (1) a comparative study of ultrastructural features of mast cells in spontaneous and reactive (pathergic) lesions of the process and in apparently uninvolved skin of patients in the active stage of the disease; (2) comparative estimation of the histamine content at the site of cutaneous hyperreactivity lesions and in apparently uninvolved skin of the same patients. Various forms and degrees of degranulation were revealed among the mast cells. These forms were obviously more frequent in spontaneous and reactive lesions than in the uninvolved skin, 66 and 56% as compared with 7.7%. Also the histamine content was twofold more in the reactive lesions than in the unaffected skin of the same patient, 43 ng/mg tissue as compared with 21 ng/mg tissue. The results of our study seem suggestive of an active role of mast cells in this process. The role is probably similar to that of basophils in cutaneous basophilic hypersensitivity.
为评估肥大细胞在白塞病黏膜皮肤病变发病机制中的作用，进行了以下研究：（1）对疾病活动期患者病程中的自发性和反应性（同形反应性）病变以及外观未受累皮肤中肥大细胞的超微结构特征进行比较研究；（2）对同一患者皮肤高反应性病变部位和外观未受累皮肤中的组胺含量进行比较评估。在肥大细胞中发现了各种形式和程度的脱颗粒现象。这些形式在自发性和反应性病变中明显比未受累皮肤中更常见，分别为66%和56%，而未受累皮肤中为7.7%。同一患者反应性病变中的组胺含量也比未受累皮肤中的组胺含量高出两倍，分别为43 ng/mg组织和21 ng/mg组织。我们的研究结果似乎表明肥大细胞在这一过程中发挥了积极作用。其作用可能与皮肤嗜碱性粒细胞超敏反应中嗜碱性粒细胞的作用类似。
