Lampman R M, Santinga J T, Bassett D R, Savage P J
Diabetes. 1981 Jul;30(7):618-20. doi: 10.2337/diab.30.7.618.
Sixty-eight determination of in vivo insulin resistance were conducted in 35 males (aged 29-63 yr) by measurement of steady-state plasma glucose levels during a combined intravenous infusion of propranolol, epinephrine, glucose, and insulin. Subjects were mildly diabetic and/or hyperlipidemic. All were asymptomatic, denied taking medication, and had no history of cardiac disease. All had normal resting electrocardiograms. During the infusion, mean increases in systolic and diastolic blood pressure were 27 +/- 12.2 (x +/- SD) and 14 +/- 5.7 mm Hg, respectively; mean reduction in heart rate was 19 +/- 6.1 beats/min. Six out of the 35 subjects developed cardiac arrhythmias during the infusion test. Maximal exercise treadmill tests failed to predict all subjects who subsequently developed arrhythmias during the infusion test. These results suggest that this infusion test should be performed under continuous cardiac monitoring and promptly terminated if major arrhythmias develop.
通过在联合静脉输注普萘洛尔、肾上腺素、葡萄糖和胰岛素期间测量稳态血浆葡萄糖水平，对35名男性（年龄29 - 63岁）进行了68次体内胰岛素抵抗测定。受试者为轻度糖尿病患者和/或高脂血症患者。所有受试者均无症状，否认服用药物，且无心脏病史。所有受试者静息心电图均正常。在输注过程中，收缩压和舒张压的平均升高分别为27±12.2（x±标准差）和14±5.7 mmHg；心率平均降低19±6.1次/分钟。35名受试者中有6名在输注试验期间出现心律失常。最大运动平板试验未能预测所有在输注试验期间随后出现心律失常的受试者。这些结果表明，该输注试验应在持续心脏监测下进行，如果出现严重心律失常应立即终止。
