LeWinter M M, Crawford M H, Karliner J S, ORourke R A
Clin Pharmacol Ther. 1975 Jun;17(6):709-12. doi: 10.1002/cpt1975176709.
The effects of oral propranolol were evaluated in 10 normal volunteers. The resting heart rate decreased from the mean control value of 68 plus or minus 3.3 (SE) to 56 plus or minus 2.8 beats per minute (bpm) on propranolol (p smaller than 0.001, paired test). Mean systolic blood pressur also decreased from 125 plus or minus 5.0 to 114 plus or minus 4.2 mm Hg (p smaller than 0.03). Resting systolic time intervals were unaffected by propranolol. Mean maximal treadmill exercise tolerance time was not significantly altered by propranolol although the mean heart rate systolic blood pressure product a maximal exertion was markedly decreased (1.91 plus or minus 0.17 vs 2.62 plus or minus 0.17 times 10-4, p smaller than 0.004) . The nonsignificant effect of oral propranolol on resting systolic time intervals and maximum exercise tolerance despite significant changes in heart rate and blood pressure at rest and duringexercise stand in contrast to the reported effects of intravenous propranolol. Explantations for this difference between the effects of oral and intravenous propranolol in normal subjects are examined.
对10名正常志愿者评估了口服普萘洛尔的效果。静息心率从平均对照值68±3.3（标准误）降至服用普萘洛尔时的56±2.8次/分钟（p<0.001，配对检验）。平均收缩压也从125±5.0降至114±4.2 mmHg（p<0.03）。静息收缩期时间间期不受普萘洛尔影响。尽管最大运动时的平均心率收缩压乘积显著降低（1.91±0.17对2.62±0.17×10⁻⁴，p<0.004），但普萘洛尔对平均最大跑步机运动耐受时间无显著改变。口服普萘洛尔对静息收缩期时间间期和最大运动耐受无显著影响，尽管静息和运动时心率及血压有显著变化，这与静脉注射普萘洛尔的报道效果形成对比。研究了正常受试者口服和静脉注射普萘洛尔效果差异的原因。
