壁细胞迷走神经切断术及伴有或不伴有引流的全迷走神经切断术对大鼠十二指肠溃疡的影响。

The effect of a parietal cell vagotomy and truncal vagotomy with and without drainage on duodenal ulcers in the rat.

作者信息

Joffe S N, Crocket A

出版信息

Digestion. 1981;22(1):47-56. doi: 10.1159/000198594.

DOI:10.1159/000198594

Abstract

The gastric secretagogues, pentagastrin and carbachol, produced a 100% incidence of duodenal ulcers. Truncal vagotomy (TV) and parietal cell vagotomy (PCV) prevented these experimental ulcers in the early post-operative period. At 3 weeks TV rats showed a decrease in weight gain, gross gastric distension and the infusion of gastric secretagogues now caused hypersecretory-induced gastric ulcers. TV and gastroenterostomy rats developed stomal ulceration and PCV failed to prevent formation of duodenal ulcers at 3 weeks. These results indicate that vagotomy, irrespective if truncal or highly selective, only has a temporary effect. This may be due to ischaemia or an altered sensitivity of the parietal cell mass with a post-operative recovery.

摘要

胃促分泌素、五肽胃泌素和卡巴胆碱可导致十二指肠溃疡的发生率达100%。迷走神经干切断术（TV）和壁细胞迷走神经切断术（PCV）可在术后早期预防这些实验性溃疡。术后3周时，TV大鼠体重增加减少、胃明显扩张，注入胃促分泌素会引发高分泌性胃溃疡。TV和胃肠吻合术大鼠出现吻合口溃疡，而PCV在术后3周未能预防十二指肠溃疡的形成。这些结果表明，无论迷走神经切断术是截断性的还是高度选择性的，都只有暂时的效果。这可能是由于缺血或壁细胞群敏感性改变以及术后恢复所致。