Krustev L P, Kamenova B B
Gegenbaurs Morphol Jahrb. 1981;127(1):12-9.
White male Wistar rats were treated with 6 and 10 mg/kg of Aflatoxin Bi intraperitoneally. 3 h afterwards, they were decapitated and their livers processed after the classical histological methods for electron microscopy as well as after the method of Gomory-Holt for acid phosphatase in liver tissue. The ultrastructural changes affected the nucleus and its chromatin; the rough and smooth endoplasmic reticulum were vacuolised; the Golgi apparatus was activated; the autophagic function of the hepatocyte lysosomes was underlined, as well as the heterophagic in the Kupffer cells. The findings are discussed as signs of early degenerative process, or of lipophanerosis.
将6毫克/千克和10毫克/千克的黄曲霉毒素B1腹腔注射给雄性白色Wistar大鼠。3小时后，将它们断头，并按照经典组织学方法对其肝脏进行处理，以用于电子显微镜检查，同时按照戈莫里 - 霍尔特法对肝组织中的酸性磷酸酶进行检测。超微结构变化影响了细胞核及其染色质；粗面和滑面内质网出现空泡化；高尔基体被激活；强调了肝细胞溶酶体的自噬功能以及库普弗细胞中的异噬功能。这些发现被作为早期退行性过程或脂肪变性的迹象进行了讨论。
